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Isolation of equine herpesvirus-1 mutants in the presence of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine: demonstration of resistance in vitro and in vivo

✍ Scribed by Hugh J. Field; Aftab R. Awan; Ricardo de la Fuente


Book ID
118392443
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
847 KB
Volume
16
Category
Article
ISSN
0166-3542

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Efficacy of (S)-1-(3-hydroxy-2-phosphony
✍ Johan Neyts; Jan Balzarini; Lieve Naesens; Erik de Clercq πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 540 KB

## Abstract Mice with severe combined immunodeficiency (SCID) inoculated intraperitoneally with murine cytornegalovirus (MCMV) develop a wasting syndrome at 3–4 days and die at 6–9 days after the infection. 9‐(1,3‐Dihydroxy‐2‐propoxyrnethyl)guanine (DHPG, ganciclovir) and (__S__)‐1‐(3‐hydroxy‐2‐pho