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Isolation of a yeast artificial chromosome clone that spans the (12;16) translocation breakpoint characteristic of myxoid liposarcoma

โœ Scribed by Robert M. Gemmill; Michael J. Mendez; Cynthia M. Dougherty; Sylvie Paulien; Martha Liao; Deanna Mitchell; Sheryl A. Jankowski; Jeffrey M. Trent; Carol Berger; Avery A. Sandberg; Paul S. Meltzer


Book ID
119105510
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
487 KB
Volume
62
Category
Article
ISSN
0165-4608

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A subgroup of pleomorphic adenomas of the salivary glands is characterized by translocations involving chromosome 8, with consistent breakpoints at 8q 12. As part of a positional cloning effort to isolate the gene(s) affected by these translocations we now report the mapping of the 8q I 2 breakpoint