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Isolation of a tumor-associated transplantation antigen (TATA) from an SV40-induced sarcoma. Resemblance to the TATA of chemically induced neoplasms

✍ Scribed by Garrett C. Dubois; Ettore Appella; Lloyd W. Law

Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
568 KB
Volume
34
Category
Article
ISSN
0020-7136

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✦ Synopsis

A tumor rejection antigen (TATA), obtained from the cytosol of a BALB/c mKSA sarcoma induced by SV40 virus, has been partially purified. This partially purified antigen is strikingly immunogenic against mKSA, providing more than 90% inhibition of growth at levels of 10-30 pg. This antigen preparation does not protect against challenge with another SV40-induced BALBk sarcoma VLM which, however, shares a group-specific T A T A with mKSA. The antigen also does not immunize against challenge with the methylcholanthrene-induced sarcomas of BALB/c mice, Meth A, CI-4, Cll-7 and Cll-10, each of which has its own unique TATA. Binding assays, using EUSA, failed to detect any SV40 antigen in the antigen preparation despite the fact that the large T antigen of SV40 (or fragments of it) constitutes the immunodominant T A T A of mKSA.

📜 SIMILAR VOLUMES

Separation of the tumor-associated trans
Separation of the tumor-associated transplantation antigen (TATA) from the alien H-2k antigens expressed on a methylcholanthrene-induced tumor
✍ Michael J. Rogers; Lloyd W. Law; Macro Pierotti; Giorgio Parmiant 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 462 KB 👁 2 views

## Abstract The tumor‐associated transplantation antigen (TATA), alien H‐2^k^ antigens and normal H‐2^d^ antigens expressed on a methylcholanthrene‐induced tumor were monitored during gel filtration and lectin affinity chromatography of detergent‐solubilized tumor‐cell membranes. TATA was resolved

Some immunogenic and biochemical propert
Some immunogenic and biochemical properties of tumor-associated transplantation antigens (TATA) obtained in soluble form or solubilized from two methylcholanthrene-induced sarcomas, meth A and CI-4
✍ Michael J. Rogers; Lloyd W. Law 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 718 KB

## Abstract The subcellular distribution of the tumor‐associated transplantation antigens (TATAs) of two highly immunogenic methylcholanthrene‐induced sarcomas, Meth A and CI‐4, were compared. Most of the TATA of CI‐4 was found in the soluble fraction (cytosol) of the cell while the TATA from Meth