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Isolation of a Human Brain cDNA for Glutamate Dehydrogenase

✍ Scribed by Carl Banner; Sanford Silverman; John W. Thomas; Keith A. Lampel; Ljubisa Vitkovic; Diana Huie; Robert J. Wenthold

Book ID: 111174251
Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 885 KB
Volume: 49
Category: Article
ISSN: 0022-3042
DOI: 10.1111/j.1471-4159.1987.tb03422.x

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## Abstract Glutamate dehydrogenase (GDH) catalyzes the oxidative deamination of glutamate to α‐ketoglutarate using NAD or NADP as cofactors. In mammalian brain, GDH is located predominantly in astrocytes, where it is probably involved in the metabolism of transmitter glutamate. The exact mechanism