Isolation of a hamster cDNA homologous to the mouse and human cyclin kinase inhibitory protein p27Kip1
β Scribed by Hemant Parekh; Kodandaram Pillarisetti; Satya Kunapuli; Henry Simpkins
- Book ID
- 110621371
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 714 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1572-9931
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## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio
We have isolated a novel cDNA that encodes a product showing significant sequence homology (56% identity) to human NIP3, a protein thought to interact with adenovirus E1B19kD and human BCL2 proteins. This cDNA contains an open reading frame of 657 nucleotides encoding a 219 amino acid polypeptide. T