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Isolation of a cyclitol antibiotic: 2,3,4,5-tetrahydroxycyclohexanemethanol

✍ Scribed by T. W. Miller; B. H. Arison; G. Albers-Schonberg

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
248 KB
Volume
15
Category
Article
ISSN
0006-3592

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✦ Synopsis

Abstract

The isolation and structure determination of a new microbial product, (+)‐ (123/45)‐2,3,4,5‐tetrahydroxy‐1‐cyclohexanemethanol is described. This product was detected in the fermentation broth of a newly isolated actinomycete by its antibacterial activity. A novel isolation method was developed and crystalline product was obtained in good yield. The structure was determined by spectroscopic examination of the product and its acetyl and trimethylsilyl derivatives. The racemic form of this compound had already been synthezised by G. E. McCasland et. al., as analog of galactose.

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