It was demonstrated that rapamycin is metabolized in vitro by pig liver microsomes under the inΓuence of the cytochrome P450-dependent mixed function oxygenase system to a rapamycin tris-epoxide metabolite, as demonstrated by electrospray tandem mass spectrometry . The in vitro immunosuppressive act
β¦ LIBER β¦
Isolation, identification and biological activity of a phyllanthoside metabolite produced in vitro by mouse plasma
β Scribed by Dennis E. Chapman; David J. Moore; Deborah C. Melder; Alan Breau; Garth Powis
- Book ID
- 104888452
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 455 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0344-5704
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## Abstract Different tacrolimus epoxides and dihydrodiol epoxides arising from the chemical oxidation of the parent drug are described. Openβchain tautomeric forms involving the lactone function were identified for the tacrolimus epoxides. Moreover, the identification by electrospray and electrosp