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Isolation, characterization and idiotype of Lewis rat antibodies against peptide 68–88 of guinea pig myelin basic protein

✍ Scribed by Robert B. Fritz; Anne E. Desjardins; Raymond Shapira

Book ID
119089187
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
646 KB
Volume
19
Category
Article
ISSN
0161-5890

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## Abstract The highly encephalitogenic guinea pig peptide 68‐88 has been used to develop an effective and reproducible model of protection in the Lewis rat. Doses as low as 0.1 nmol of peptide protected 70% of rats when injected intraperitoneally six and four weeks prior to challenge with 0.05 nmo

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Immunochemical analysis of polyclonal antisera from Lewis rats immunized with peptide analogs and subpeptides of residues 72-84 of guinea pig myelin basic protein (MBP) indicated that there were four main epitopic specificities involved: one represented by residues 76-80, one by residues 72-74, one