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Isolation and the fluorometric, high-performance liquid chromatographic determination of tacrine

✍ Scribed by Thomas H. Park; Ken H. Tachiki; William K. Summers; David Kling; Jaime Fitten; Kent Perryman; Karen Spidell; Arthur S. Kling

Publisher: Elsevier Science
Year: 1986
Tongue: English
Weight: 340 KB
Volume: 159
Category: Article
ISSN: 0003-2697
DOI: 10.1016/0003-2697(86)90353-2

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✦ Synopsis

Tacrine (THA; 1,2,3,4-tetrahydro-9-aminoacridine) is an anticholinesterase agent which has been used clinically, most recently in the treatment of Alzheimer-type dementias. This paper describes the methodology for the isolation and quantitation of THA at therapeutic levels in serum from human subjects. Using C18 Bond Elut columns and an HPLC/fluorometry system, this assay exhibits a considerable improvement in sensitivity over previous uv methods, and allows routine testing of THA levels in serum samples of reasonable volume from human subjects.

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