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Isolation and structure of the exceptional Pterobranchia human cancer inhibitors cephalostatins 16 and 171

โœ Scribed by George R. Pettit; Jun-Ping Xu; Jean M. Schmidt; Michael R. Boyd


Book ID
108038882
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
233 KB
Volume
5
Category
Article
ISSN
0960-894X

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Phakellistatins 7-9 respresent the first cancer cell growth inhibitory (P388 ED50 3.0, 2.9 and 4.1 Ixg/mL respectively) cyclic decapeptides. Each was isolated from the Federated States of Micronesia (Chunk) marine sponge Phakellia costata. Animals, plants and microorganisms constitute a vast reserv