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Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9

โœ Scribed by Pettit, George R.; Cichacz, Zbigniew A.; Herald, Cherry L.; Gao, Feng; Boyd, Michael R.; Schmidt, Jean M.; Hamel, Ernest; Bai, Ruoli


Book ID
120640399
Publisher
The Royal Society of Chemistry
Year
1994
Tongue
English
Weight
292 KB
Volume
13
Category
Article
ISSN
0022-4936

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Phakellistatins 7-9 respresent the first cancer cell growth inhibitory (P388 ED50 3.0, 2.9 and 4.1 Ixg/mL respectively) cyclic decapeptides. Each was isolated from the Federated States of Micronesia (Chunk) marine sponge Phakellia costata. Animals, plants and microorganisms constitute a vast reserv