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Isolation and Refined Regional Mapping of Expressed Sequences from Human Chromosome 21

✍ Scribed by Fa-Ten Kao; Jingwei Yu; Suhong Tong; Jianxin Qi; Sankhavaram R. Patanjali; Sherman M. Weissman; David Patterson

Book ID
115612409
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
236 KB
Volume
23
Category
Article
ISSN
0888-7543

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The transcription start sites of many genes are associated with CpG-rich DNA regions (CpG islands) containing clusters of rare cutting, methylation-sensitive restriction enzyme sites [Bird, 1986]. To detect gene sequences from human chromosome 21, we have screened cloned DNA fragments from a chromos