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Isolation and identification of a mevalonolactone by-product formed during the assay for 3-hydroxy-3-methylglutaryl coenzyme a reductase activity

โœ Scribed by Sanghvi, Ajit; Parikh, Bharat


Book ID
121962985
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
333 KB
Volume
444
Category
Article
ISSN
0304-4165

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We have used a cDNA clone for Chinese hamster 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase to isolate a genomic recombinant for human HMG-CoA reductase. The identity of the gene was confirmed by partial sequence analysis. Several unique fragments that will be useful for restriction frag