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Isolation and characterization of urinary metabolites of nalorphine in dogs and cats

โœ Scribed by S. Y. Yeh; L. A. Woods

Publisher
John Wiley and Sons
Year
1971
Tongue
English
Weight
355 KB
Volume
60
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

Nalorphine-3-glucuronide dihydrate and nalorphine-6-glucuronide were isolated as urinary metabolites of nalorphine in dogs, and nalorphine-3-ethereal sulfate and nalorphine-3-glucuronide dihydrate were isolated in cats. These metabolites were characterized by UV and IR spectra, phenolic test, nalorphine and glucuronic acid determinations, elemental analyses, and enzymatic hydrolysis.

Keyphrases 0 Nalorphine, urinary metabolites-isolation, characterization, in dogs, cats I J TLC-separation 0 Paper chromatography-separation 0 UV spectrophotometry-identification 0 IR spectrophotometry-identification Nalorphine is N-dealkylated to normorphine in vitro by rat liver microsomes (1) and in vivo in rats (2) and cats (3), and it is conjugated in rats (4) and dogs ACKNOWLEDGMENTS AND ADDRESSES

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