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Isolation and characterization of amphotericin B-resistant cell lines in Chinese hamster cells

✍ Scribed by Hidaka, Katsuhiko; Endo, Hideya; Akiyama, Shin-ichi; Kuwano, Michihiko


Book ID
121996235
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
656 KB
Volume
14
Category
Article
ISSN
0092-8674

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Amphotericin B resistance is recessive i
✍ Katsuhiko Hidaka; Shin-Ichi Akiyama; Michihiko Kuwano πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 English βš– 486 KB

## Abstract Previous studies from our laboratory have shown that Chinese hamster V79 cells mutated to high level resistance to amphotericin B have a lower cellular level of cholesterol, the target molecule for the polyene antibiotic. Two amphotericin B‐resistant (AMB^R^) mutants were each hybridize