Isolation and Biosynthetic Pathway for Citreohybridones from the Hybrid Strain KO 0031 Derived from Penicillium Species

✍ Scribed by Seiji Kosemura; Shosuke Yamamura

• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 573 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)01430-5

✦ Synopsis

Five newmetabolizes, citreohybridones D -G andisocitreohybridone G, havebeenisolatsd from the mycelium of the hybridstrain KO 0031 derivedfrom Penicillium citreo-viride B. IFO 6200 and4692. Their sterecktmctursshave beenalso elucidated on the basis of their spsctral dataand some chemicalevidence,anda biosyntheticpathwayfor citreohybridones is proposed. @ 1997Elsevier Science Ltd.

describedin the previouspapers,'-swe have succeededin isolatingseveralnew highly potent antifeedingmetabolizes, citrcohybndonesA (1) and B (2) and citreohybriddione C (3) and others, against Plutellaxylostella fromthe myceliumof the hybridstrainKO 0031derivedfromPenicillituncitreo-viride B. IFO 6200 and 4692. Recently, Omttra et al. isolated andrastins A, B and C (4)', new protein famesyltransferase inhibitors, from PeniciZZiarn sp. FO-3929and determinedtheir absoluteconfiguration. Interestingly,it is clear that these metabolizesmust be precursorsof citreohybridones.3'4 In view of the biologicalsignificanceof these uniquemeroterpenoids (mixedpolyketide-terpenoid)'"" we furtherexamined themetabolizes in themyceliumof thehybridstrainKO0031,incubatedstationarily at roomtemperature for 14 days. In this communicationwe wish to report the isolation'4and structuralelucidationof some new merote~noids, andconsideration of a proposedbiosynthetic pathwayforcitreohybridones.

Citrcohybridone D(5), [et]." -80.2°(c= 1.0, CHC1,),C#4008 [rnLz 528.2700(I@] showed'HNMR