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Isoforms of endothelin-converting enzyme-1 (ECE-1) have opposing effects on prostate cancer cell invasion

✍ Scribed by Lambert, L A; Whyteside, A R; Turner, A J; Usmani, B A

Book ID
109999725
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
203 KB
Volume
99
Category
Article
ISSN
0007-0920

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## Abstract The zinc metalloprotease, endothelin‐converting enzyme‐1 (ECE‐1), which converts the mitogenic peptide endothelin‐1 (ET‐1) from its biologically inactive precursor big‐ET‐1, is commonly upregulated in prostate cancer (PC) cells. Consequently, we have sought to suppress ECE‐1 expression