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Isoform-selective phosphoinositide 3-kinase inhibitors induce apoptosis in chronic lymphocytic leukaemia cells

✍ Scribed by Mercè De Frias; Daniel Iglesias-Serret; Ana M. Cosialls; Diana M. González-Gironès; Alba Pérez-Perarnau; Camila Rubio-Patiño; Thomas Rückle; Montserrat Camps; Alberto Fernández De Sevilla; Esmeralda De La Banda; Gabriel Pons; Joan Gil


Book ID
108676745
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
222 KB
Volume
150
Category
Article
ISSN
0007-1048

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## Abstract B‐cell chronic lymphocytic leukaemia (B‐CLL) cells fail to undergo apoptosis. The mechanism underlying this resistance to cell death is still largely unknown. Tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL) effectively kills tumour cells but not normal cells, and thus r