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Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells

✍ Scribed by Hahntow, I N; Schneller, F; Oelsner, M; Weick, K; Ringshausen, I; Fend, F; Peschel, C; Decker, T

Book ID: 110055822
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 284 KB
Volume: 18
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2403295

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## Abstract Inhibitors of cyclin‐dependent kinases (CDKs) undergoing clinical trials as anticancer agents usually target several CDKs in cells. Some of them are also able to increase cellular levels of p53 protein and to activate p53‐regulated transcription. To define the role of p53 in the antican