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Isoelectric focusing studies on the PGM1 subtypes in the northern Japanese population

✍ Scribed by Sebetan, I.M. ;Kudo, T. ;Hiraiwa, K. ;Ohno, Y. ;Kuroda, F. ;Akaishi, S.

Publisher: Springer-Verlag
Year: 1982
Tongue: English
Weight: 563 KB
Volume: 88-88
Category: Article
ISSN: 1437-1596
DOI: 10.1007/bf00200735

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✦ Synopsis

The distribution of the human red cell phosphoglucomutase (PGM1) subtypes in samples from Japanese population (n--277) living in the Miyagi Prefecture, the northern part of Japan, was investigated by applying the thinlayer polyacrylamide gel isoelectric focusing. In our population sample all the ten common phenotypes were demonstrated, and the estimated allele frequencies for the genes PGM] +, PGMI-, PGM~ +, and PGM~-were 0.671,0.107, 0.161, and 0.061, respectively. Family studies (n = 40) indicated an autosomal codominant inheritance and confirmed the four alleles. The new system wilt increase the probability of exclusion in paternity cases among Japanese to 29.4% compared with 14.3% if the two allele system is used.

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