Islet-cell and insulin autoantibodies in diabetes
β Scribed by Helga Gleichmann; GianFranco Bottazzo
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 701 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0167-5699
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π SIMILAR VOLUMES
IgG and IgM class insulin autoantibodies were measured by an enzyme-linked immunosorbent assay in sera from members of the Barts-Windsor-Middlesex prospective family study for Type I (insulin-dependent) diabetes. One hundred and twelve individuals from 28 families were selected for study on the basi
Blood was drawn from 74 children, 3-16 years old, at diagnosis of Type 1 (insulin-dependent) diabetes and before the first insulin injection. Insulin autoantibodies were detected with a polyethylen-glycol-method in 27/74 (36.4%) and with an immuno-electrophoretic method in 6/74 (8.1%). Islet cell cy
Genetic determination as well as prospective analysis of islet cell autoantibodies and autoantibodies to insulin were conducted in a population of 479 first degree relatives of 174 Type 1 (insulin-dependent) diabetic patients. Analysis of HLA haplotypes within families illustrated the high frequency