Genetic determination as well as prospective analysis of islet cell autoantibodies and autoantibodies to insulin were conducted in a population of 479 first degree relatives of 174 Type 1 (insulin-dependent) diabetic patients. Analysis of HLA haplotypes within families illustrated the high frequency
β¦ LIBER β¦
Prevalence of cytoplasmatic islet cell antibodies and insulin autoantibodies is increased in subjects with genetically defined high risk for insulin-dependent diabetes mellitus
β Scribed by Kuglin, B. ;Bertrams, J. ;Linke, C. ;Gries, F. A. ;Kolb, H.
- Publisher
- Springer-Verlag
- Year
- 1989
- Tongue
- English
- Weight
- 761 KB
- Volume
- 67
- Category
- Article
- ISSN
- 1432-1440
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The conventional indirect immunofluorescence test of islet cell antibodies was recently improved by the development of a two-colour immunofluorescence assay using a monoclonal proinsulin antibody to detect islet B cells. The aim of this study was to test whether in this new assay the prevalence and