## Abstract The prodynorphin gene (__PDYN__) encoding the anticonvulsant peptide dynorphin is a strong candidate for a seizure suppressor gene and thus a possible modulator of susceptibility to temporal lobe epilepsy. We performed a case control association study in 155 patients with nonlesional te
Is Variation in the GABA(B) Receptor 1 Gene Associated with Temporal Lobe Epilepsy?
β Scribed by Nigel C.K. Tan; Sarah E. Heron; Ingrid E. Scheffer; Samuel F. Berkovic; John C. Mulley
- Book ID
- 109108718
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2005
- Tongue
- English
- Weight
- 51 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0013-9580
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Molecular biology tools have been employed to investigate the participation of peptides in human temporal lobe epilepsy (TLE). Active polypeptides and their receptors have been related to several brain processes, such as inflammation, apoptosis, brain development, K^+^ and Ca^2+^ channe
Proinflammatory cytokines, including interleukin (IL)-1β€, are known to modulate effects of neurotoxic neurotransmitters discharged during excitation or inflammation in the central nervous system (CNS). They also regulate development of glial scars at sites of CNS injury. To elucidate a genetic predi