Is tolerance the result of engaging surface Ig of B cells in cycle?
β Scribed by David W. Scott; Norman R. Klinman
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 291 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0167-5699
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This study tracks the fate of antigen-reactive B cells through follicular and extrafollicular responses and addresses the function of CD40 in these processes. The unique feature of this system is the use of transgenic B cells in which the heavy chain locus has been altered by site-directed insertion
There has been considerable recent progress in the characterization of the regulatory T cells that mediate tolerance in a number of transplantation models. The conditions that facilitate the generation of regulatory T cells point to the thymus, the nature of immune suppression and the dose of immuno