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Is there an association between the effects of clozapine on the production of reactive oxygen metabolites by blood monocytes and clinical outcome in neuroleptic-resistant schizophrenia?

✍ Scribed by G. Joffe; P. Nyberg; A. Gross; B. Appelberg

Book ID: 119560161
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 95 KB
Volume: 29
Category: Article
ISSN: 0920-9964
DOI: 10.1016/s0920-9964(97)88746-4

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The production of reactive oxygen metabolites (ROM) by monocytes (MO) and polymorphonuclear leukocytes (PMNL) from eight patients with neuroleptic-resistant schizophrenia was measured before and after 3 and 10 weeks of clozapine (CLO) treatment. Although ROM production did not show signi®cant longit

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Reactive oxygen metabolites (ROM), produced by mononuclear phagocytes may participate in brain pathology. Clozapine (CLO) may modulate cell immunity, and it is also superior to conventional neuroleptics in conditions with a putative impact of oxidative damage by ROM, i.e. negative symptoms and neuro