Is there an association between the effects of clozapine on the production of reactive oxygen metabolites by blood monocytes and clinical outcome in neuroleptic-resistant schizophrenia?

✍ Scribed by Grigori Joffe; Peter Nyberg; Andres Gross; Björn Appelberg

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 129 KB
• Volume: 13
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/(sici)1099-1077(199806)13:4<231::aid-hup976>3.0.co;2-j

✦ Synopsis

The production of reactive oxygen metabolites (ROM) by monocytes (MO) and polymorphonuclear leukocytes (PMNL) from eight patients with neuroleptic-resistant schizophrenia was measured before and after 3 and 10 weeks of clozapine (CLO) treatment. Although ROM production did not show signi®cant longitudinal trends during the trial, the changes in ROM production by non-stimulated (Mon) and phorbol myristate acetate (PMA)-stimulated MO (MOs) at week 3 (values at base-line minus those at week 3) correlated positively (r 0 . 743, p 0 . 035, and r 0 . 838, p 0 . 009, respectively) with the changes on the total Positive and Negative Syndrome Scale (PANSS) scores, i.e. a decrease or relatively small increase in the ROM production by MOn and MOs was associated with more favourable clinical outcome than a clear-cut increase in their ROM production. The serum concentrations of CLO at week 3 also correlated positively with the changes in ROM production by MOs at week 3 (r 0 . 761, p 0 . 047) and at week 10 (r 0 . 985, p 5 0 . 001). A possible causal relationship between these observations and the mechanism of action of CLO is discussed.