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Is there an altered steroid profile in patients with endometrial carcinoma?

✍ Scribed by Gunnar Möllerström; Kjell Carlström; Anders Lagrelius; Nina Einhorn

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
941 KB
Volume
72
Category
Article
ISSN
0008-543X

No coin nor oath required. For personal study only.

✦ Synopsis

Background. Besides the well-known association between endometrial carcinoma (EC) and unopposed estrogen, androgens also may play a role in this respect; however, previous studies on endogenous estrogens and androgens in patients with EC and control subjects have yielded mostly divergent results, probably because of the use of poorly defined control groups.

Circulating steroid and pituitary hormones and sex hormone-binding globulin were measured in patients with EC and matched control groups of either patients with nonmalignant postmenopausal bleeding (hospital control subjects) and healthy, symptom-free women (nonhospital control subjects).

Patients with EC had higher serum levels of adrenal C,, and C,, steroids, estrogens, and biologically active testosterone than nonhospital control subjects, whereas the hospital control subjects constituted an intermediate group in this respect.

The results clearly indicate an altered steroid homeostasis, probably reflectingan increased "adrenal drive" in patients with EC. The results also stress the necessity of using strictly defined, healthy, symptomfree control subjects instead of the frequently used hospital control subjects when studying more subtile endocrine aberrations. Cancer 1993

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