Is There a Role for Antibody in the Pathogenesis of Spontaneous Diabetes in the BB Rat?
โ Scribed by STEPHEN J. PROWSE; DONALD BELLGRAU; KEVIN J. LAFFERTY
- Book ID
- 118723368
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 111 KB
- Volume
- 475
- Category
- Article
- ISSN
- 0890-6564
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๐ SIMILAR VOLUMES
The diabetic syndrome of the BB rat shows many homologies with that of human insulin-dependent diabetes and evidence that the onset of the disease is associated with the presence of autoantibodies, including islet cell surface antibodies. In this study, sera were sampled serially from weaning to 157
Sera from BB Wistar rats and Wistar control rats were evaluated for the presence of islet cell antibodies in a prospective study using an indirect immunofluorescence assay on pancreatic islet cell suspensions from cultured rat islets. Islet cell surface antibodies were detected in sera from all anim