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An immunofluorescence study of anti-pancreatic islet cell antibodies in the spontaneously diabetic BB Wistar rat

✍ Scribed by D. R. Pollard; K. Gupta; L. Mancino; I. Hynie

Publisher: Springer
Year: 1983
Tongue: English
Weight: 478 KB
Volume: 25
Category: Article
ISSN: 0012-186X
DOI: 10.1007/bf00251898

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✦ Synopsis

Sera from BB Wistar rats and Wistar control rats were evaluated for the presence of islet cell antibodies in a prospective study using an indirect immunofluorescence assay on pancreatic islet cell suspensions from cultured rat islets. Islet cell surface antibodies were detected in sera from all animals of the spontaneously diabetic BB Wistar rat colony. The antibody could be detected well before the clinical onset of the disease and was present throughout the course of study of all diabetic animals. Sera from control Wistar rats were negative when tested for this antibody.

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The diabetic syndrome of the BB rat shows many homologies with that of human insulin-dependent diabetes and evidence that the onset of the disease is associated with the presence of autoantibodies, including islet cell surface antibodies. In this study, sera were sampled serially from weaning to 157