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Is there a characteristic dermal involvement in amyotrophic lateral sclerosis?

✍ Scribed by Giorgio Mapelli


Book ID
118931082
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
123 KB
Volume
95
Category
Article
ISSN
0022-510X

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## Abstract ## Objective To elucidate the role of cyclooxygenase‐1 (Cox1) and prostaglandin E~2~ in ALS neurodegeneration. ## Methods Mutation in superoxide dismutase‐1 is a cause of the fatal paralytic disorder amyotrophic lateral sclerosis. Inhibition of cyclooxygenase‐2 (Cox‐2) in transgenic