We describe a patient with acute myeloblastic leukemia (AML-M0) whose cells had a t(2;11)(p21;q23). Fluorescence in situ hybridization analysis with a probe for MLL showed that it was split, hybridizing to both the derivative 2 and 11 chromosomes. Nineteen other patients with 2p;11q translocations h
Is t(10;11)(p11.2;q23) involving MLL and ABI-1 genes associated with congenital acute monocytic leukemia?
β Scribed by Cristina Morerio; Cristina Rosanda; Annamaria Rapella; Concetta Micalizzi; Claudio Panarello
- Book ID
- 114135422
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 97 KB
- Volume
- 139
- Category
- Article
- ISSN
- 0165-4608
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## Abstract The recurrent translocation t(10;11) is associated with acute myeloid leukemia (AML). The __AF10__ gene on chromosome 10 at band p12 and __MLL__ at 11q23 fuse in the t(10;11)(p12;q23). Recently, we have identified __ABI1__ as a new partner gene for __MLL__ in an AML patient with a t(10;
The human trithorax homolog gene (MLL) is directly involved in over 90% of cases of acute leukemia with abnormalities of I I q23. However, involvement of other genes at I I q23 both centromeric and telomeric of MLL has been identified in different subtypes of leukemia and lymphoma. We describe a cas