Is screening for thyroid carcinoma indicated in familial adenomatous polyposis?
✍ Scribed by C. Bülow; S. Bülow; and the Leeds Castle Polyposis Group
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 101 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0179-1958
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## Communicated by Kenshi Hayushi We report here the result of a screening for germ-line mutations in the adenomatous polyposis coli (APC) gene in 61 new familial adenomatous polyposis (FAP) patients as well as a summary of the results of 150 patients. Examination of the entire coding region of th
Germline mutations in the APC gene are responsible for familial adenomatous polyposis (FAP), a dominantly inherited syndrome characterized by the development of hundreds to thousands of polyps in the colon and in the rectum of affected individuals and by variable extracolonic manifestations (gastric