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Is pyridoxine helpful in preventing palmar-plantar erythrodysesthesia associated with capecitabine?

โœ Scribed by Hei Cheul JEUNG; Hyun Cheol CHUNG


Book ID
111318839
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
77 KB
Volume
6
Category
Article
ISSN
1743-7555

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Pyridoxine therapy for palmar-plantar er
โœ Carol J. Fabian; Roy Molina; Milan Slavik; Steve Dahlberg; Shankar Giri; Ronald ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› Springer US ๐ŸŒ English โš– 578 KB

The limiting toxicity of low dose continuous infusion 5-fluorouracil (200-300 mg/m2/day) is often palmar-plantar erythrodysesthesia (PPE). PPE developed in 16/25 patients (exact 95% confidence interval of 42%-82%) with metastatic colon cancer enrolled in a phase II trial. In this trial, 5-FU was giv