Approximately 2% to 5% of all breast cancers are hereditary, meaning that the cancer predisposition is carried as a monogenic trait. Several highly penetrant breast cancer predisposing genes have been identified. These discoveries will permit a refined description of breast cancer occurring as part
Is BRCA1/BRCA2-related breast carcinogenesis estrogen dependent?
β Scribed by Mehadad Noruzinia; Isabelle Coupier; Pascal Pujol
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 243 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0008-543X
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## Abstract The breast cancer susceptibility genes __BRCA1__ and __BRCA2__ are responsible for a large proportion of familial breast and ovarian cancer, yet little is known of how disruptions in the functions of the proteins these genes encode increased cancer risk preferentially in hormoneβdepende