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The rs2910164:G>C SNP in the MIR146A gene is not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers

✍ Scribed by Amandine I. Garcia; David G. Cox; Laure Barjhoux; Carole Verny-Pierre; Daniel Barnes; Gemo Study Collaborators; Antonis C. Antoniou; Dominique Stoppa-Lyonnet; Olga M. Sinilnikova; Sylvie Mazoyer


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
122 KB
Volume
32
Category
Article
ISSN
1059-7794

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## Abstract Marked variation in phenotypic expression among __BRCA1__ and __BRCA2__ mutation carriers may be partly explained by modifier genes that influence mutation penetrance. Variation in CAG/CAA repeat lengths coding for stretches of glutamines in the C‐terminus of the AIB1 protein (amplified