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Is Angiopoietin-2 Necessary for the Initiation of Tumor Angiogenesis?

✍ Scribed by Juha Laurén; Yuji Gunji; Kari Alitalo


Book ID
117022868
Publisher
American Society for Investigative Pathology
Year
1998
Tongue
English
Weight
312 KB
Volume
153
Category
Article
ISSN
0002-9440

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## Background: Angiopoietin-1 (ang-1) and angiopoietin-2 (ang-2) are important regulators of endothelial cell (ec) survival. current models suggest that an increase in ang-2 expression in ecs leads to the initiation of angiogenesis. the authors hypothesized that the imbalance of ang-1 and ang-2 act