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Ca2+ Activation of RyR1 Is Not Necessary for the Initiation of Skeletal-Type Excitation-Contraction Coupling

✍ Scribed by O’Brien, Jennifer J.; Feng, Wei; Allen, Paul D.; Chen, S. R. Wayne; Pessah, Isaac N.; Beam, Kurt G.


Book ID
118515056
Publisher
Biophysical Society
Year
2002
Tongue
English
Weight
241 KB
Volume
82
Category
Article
ISSN
0006-3495

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The alpha 1 subunit of the L-type Ca2+ channel plays a dual role in skeletal muscle. It is essential both for L-type Ca2+ channel activity and for the functioning of the voltage-sensor structure that is situated in the triads as a key element for excitation-contraction coupling. This paper shows, wi