๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

IRS-1: Auditing the effectiveness of mTOR inhibitors

โœ Scribed by John B. Easton; Raushan T. Kurmasheva; Peter J. Houghton

Book ID
113523661
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
404 KB
Volume
9
Category
Article
ISSN
1535-6108

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Role of mTOR in the degradation of IRS-1
Role of mTOR in the degradation of IRS-1: Regulation of PP2A activity
โœ David Hartley; Geoffrey M. Cooper ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 274 KB

## Abstract We have investigated the role of PI 3โ€kinase and mTOR in the degradation of IRSโ€1 induced by insulin. Inhibition of mTOR with rapamycin resulted in approximately 50% inhibition of the insulinโ€induced degradation of IRSโ€1. In contrast, inhibition of PIโ€3 kinase, an upstream activator of