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Irreversible gonadal damage in male survivors of pediatric Hodgkin's disease

✍ Scribed by Janneke Heikens; Henk Behrendt; Ria Adriaanse; Arie Berghout

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 467 KB
Volume: 78
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19961101)78:9<2020::aid-cncr25>3.0.co;2-y

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✦ Synopsis

BACKGROUND.

Gonadal damage in adult patients after chemotherapy for Hodgkin's disease is well documented, but data of patients treated before adulthood are scarce.

METHODS.

Gonadal and hormonal function were studied in 19 male long term survivors of Hodgkin's disease who were treated with mechlorethamine, vincristine, procarbazine, and prednisone (MOPP chemotherapy) before (n = 15) or during puberty (n = 4). The studies were performed a median of 10 years after treatment and repeated in the majority of the patients at the time of yearly visits.

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