Irradiation induces neural precursor-cell dysfunction
β Scribed by Monje, Michelle L.; Mizumatsu, Shinichiro; Fike, John R.; Palmer, Theo D.
- Book ID
- 109933187
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 936 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1078-8956
- DOI
- 10.1038/nm749
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## Abstract Neural precursor cells (NPCs) critically regulate brain morphogenesis and recent studies have revealed an unexpectedly high frequency of NPC chromosomal abnormalities and apoptosis in the developing brain. We have shown previously that the apoptotic response of NPCs to genotoxic agents
## Abstract In this study, we examined the role of PKC in the differentiation of multipotential neural precursor cells (NPCs). We found that the NPCs expressed PKCΞ±,Ξ²2,Ξ΄,Ο΅,ΞΆ and low levels of PKCΞ³. The PKC activator, PMA, selectively increased the number of astrocytes, whereas it decreased the gene