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Iron(II) binding to anthracyclines; nucleotides and DNA, and effects on growth of fibroblasts

✍ Scribed by A. Barbieri; B.F. Matzanke; I. Di Liegro; A. Cestelli; E. Bill; A.X. Trautwein


Book ID
103570159
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
72 KB
Volume
59
Category
Article
ISSN
0162-0134

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The interaction of Fe(III), adriamycin a
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The interactions of the iron complexes of the anthracycline antitumour drugs daunomycin (DN) and adriamycin (ADM) with the mononucleotide AMP, herring sperm DNA, plasmic pBR322 and immortalized 3T3 fibroblasts were studied. By means of M6ssbauer spectroscopy it was demonstrated that DNA is a powerfu