Iron porphyrins catalyze the synthesis of non-protected amino acid esters from ammonia and diazoacetates
β Scribed by Aviv, Iris; Gross, Zeev
- Book ID
- 121658255
- Publisher
- Royal Society of Chemistry
- Year
- 2006
- Tongue
- English
- Weight
- 444 KB
- Volume
- 43
- Category
- Article
- ISSN
- 1359-7345
- DOI
- 10.1039/B609265A
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π SIMILAR VOLUMES
Papain catalyzed synthesis of glyceryl esters of BOC(Z)-protected amino acids and peptides was performed at 40-50Β°C in a 50 molar excess of glycerol. Equilibrium was achieved in 6-7 h. The maximal yield of esters (50-70%) was obtained at 10% of water and pH 3.2-3.4. A lower water concentration resul
N-Boc-u-msylsarcosine ethyl ester (3) reacts under neutral conditions either with allylic carbonates or with vinyloxinme in the presence of a catalytic amount of Pd(PPh3) 4 and dppe (5 mol%) to give regio-and stereoselectively the corresponding allylated products $ and 6, respectively. Reductive des