Iron and Copper Salts in the Synthesis of Benzo[b]furans

✍ Scribed by Julien Bonnamour; María Piedrafita; Carsten Bolm

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 178 KB
• Volume: 352
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/adsc.201000269

✦ Synopsis

Abstract

Intramolecular CO bond forming reactions of aryl 2‐bromobenzyl ketones lead to benzo[b]furans. The cyclizations can be catalyzed by 10 mol% of iron trichloride (of 98% or of 99.995% purity) or sub‐mol% quantities of copper(II) chloride (of 99.995% purity).