Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys
β Scribed by Mochizuki, Hideki; Imai, Hisamasa; Endo, Kiyonori; Yokomizo, Kazuko; Murata, Yaeko; Hattori, Nobutaka; Mizuno, Yoshikuni
- Book ID
- 122620263
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 467 KB
- Volume
- 168
- Category
- Article
- ISSN
- 0304-3940
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Primary cultures of mouse astrocytes were treated with both the monoamine oxidase (MAO) A inhibitor, clorgyline, and the MA0 B inhibitor, deprenyl, prior to the addition of the neurotoxicant 1 -methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP). Production of the 1-methyl-4-phenylpyridinium (MPP+) to