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Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells

✍ Scribed by David Davidson, Yannick Coulombe, Veronica L. Martinez-Marignac, Lilian Amrein, Jeremy Grenier, Keira Hodkinson, Jean-Yves Masson, Raquel Aloyz, Lawrence Panasci


Book ID
113064482
Publisher
Springer US
Year
2011
Tongue
English
Weight
278 KB
Volume
30
Category
Article
ISSN
0167-6997

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## Abstract Despite recent therapeutic advances, the response rates to chemotherapy for patients with metastatic colon cancer remain at ∼50% with the fluoropyrimidine, 5‐fluorouracil (5‐FU), continuing to serve as the foundation chemotherapeutic agent for the treatment of this disease. Previous stu