Iridium-Catalyzed Reactions of Trifluoromethylated Compounds with Alkenes: A CH Bond Activation α to the Trifluoromethyl Group

✍ Scribed by Yong Guo; Xiaming Zhao; Dazhi Zhang; Shun-Ichi Murahashi

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 293 KB
• Volume: 48
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200805852

✦ Synopsis

Abstract

Catalytic convenience: The use of iridium or ruthenium catalysts for CH bond activation has led to the addition reaction of trifluoromethylated compounds to alkenes (see scheme). This atom‐economical reaction occurs under neutral reaction conditions and without the formation of undesired defluorinated by‐products, even at high temperature.magnified image