Iridium-catalyzed formylation of amines with paraformaldehyde

✍ Scribed by Ourida Saidi; Mark J. Bamford; A. John Blacker; James Lynch; Stephen P. Marsden; Pawel Plucinski; Robert J. Watson; Jonathan M.J. Williams

• Book ID: 104098277
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 968 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.08.106

✦ Synopsis

Amines have been formylated using aqueous formaldehyde or paraformaldehyde and the iridium catalyst [Cp*IrI 2 ] 2 . Paraformaldehyde acts as both a formylating agent and an oxidant.