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Iridium-Catalyzed Enantioselective Allylic Alkylation of Methyl 2-(4-nitrophenylsulfonyl)acetate and Subsequent Transformations

✍ Scribed by Qing-Long Xu; Li-Xin Dai; Shu-Li You


Book ID
111992706
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
382 KB
Volume
354
Category
Article
ISSN
1615-4150

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## Abstract A broadly applicable synthesis of chiral 2‐ or 2,4‐substituted cyclopent‐2‐enones has been developed by combining asymmetric iridium‐catalyzed allylic alkylation reactions and ruthenium‐catalyzed ring‐closing metathesis. Enantiomeric excesses (__ee__ values) in the range of 95–99 % __ee