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Enantioselective Modular Synthesis of 2,4-Disubstituted Cyclopentenones by Iridium-Catalyzed Allylic Alkylation.

✍ Scribed by Mathias Schelwies; Pierre Duebon; Guenther Helmchen

Publisher
John Wiley and Sons
Year
2006
Weight
32 KB
Volume
37
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

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📜 SIMILAR VOLUMES

Preparation of 2,4-Disubstituted Cyclope
Preparation of 2,4-Disubstituted Cyclopentenones by Enantioselective Iridium-Catalyzed Allylic Alkylation: Synthesis of 2′-Methylcarbovir and TEI-9826
✍ Pierre Dübon; Mathias Schelwies; Günter Helmchen 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 432 KB

## Abstract A broadly applicable synthesis of chiral 2‐ or 2,4‐substituted cyclopent‐2‐enones has been developed by combining asymmetric iridium‐catalyzed allylic alkylation reactions and ruthenium‐catalyzed ring‐closing metathesis. Enantiomeric excesses (__ee__ values) in the range of 95–99 % __ee