[IrCl2Cp*(NHC)] Complexes as Highly Versatile Efficient Catalysts for the Cross-Coupling of Alcohols and Amines

✍ Scribed by Amparo Prades; Rosa Corberán; Macarena Poyatos; Eduardo Peris

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 247 KB
• Volume: 14
• Category: Article
• ISSN: 0947-6539
• DOI: 10.1002/chem.200801580

✦ Synopsis

Abstract

A comparative study on the catalytic activity of a series of [IrCl~2~Cp*(NHC)] complexes in several C–O and C–N coupling processes implying hydrogen‐borrowing mechanisms has been performed. The compound [IrCl~2~Cp*(I^__n__Bu^)] (Cp*=pentamethyl cyclopentadiene; I^__n__Bu^=1,3‐di‐n‐butylimidazolylidene) showed to be highly effective in the cross‐coupling reactions of amines and alcohols, providing high yields in the production of unsymmetrical ethers and N‐alkylated amines. A remarkable feature is that the processes were carried out in the absence of base, phosphine, or any other external additive. A comparative study with other known catalysts, such as Shvo's catalyst, is also reported.